Eleanor Marshall
Project
Track 18: Models to study and prioritize neuropathogenic arboviruses
Promotor
Marion Koopmans (EMC)
Primary Supervisor
Barry Rockx (EMC)
Cosupervisor
Jeroen Kortekaas (WUR)
University
Erasmus University Medical Centre
Description PhD project
Hello! I’m Eleanor, a 24-year-old English girl trying to escape Brexit. I love keeping fit via a variety of sports, especially Aussie rules football, and I recently obtained my black belt in karate. In addition to physical past times, I combine my love of nature with my creative side through landscape photography.
Following my Biomedical Science bachelors, I worked as a study-supervisor in the ELISA department of a CRO, overseeing testing of an immunotherapeutic drug. After a year at Covance, I began my masters in Infection and Immunity at Utrecht University. Here, I carried out two projects, one at University Medical Centre Utrecht on immunotherapeutics and one at the Karolinska where I identified bacterial strains inhibitive to MRSA. I was then employed in Stockholm to continue this project.
During my masters, I wrote a literature review on Orthobunyaviruses and became intrigued by the endless interplaying factors influencing vector-borne virus outbreaks. Outside my studies I have a keen interest in neuroscience, reading many popular science books on the topic, so a PhD on the neurotropism of vector-borne viruses seemed the perfect fit!
In this project I aim to identify and prioritise neurotropic viruses and use this information to inform and aid other projects within the consortium. I also aim to use my PhD as an opportunity to further develop my scientific skills and network.
Publications
Usutu virus and West Nile virus use a transcellular route of neuroinvasion across an in vitro model of the human blood-brain barrier
February, 2024
Authors: Eleanor M. Marshall, Marion Koopmans, Barry Rockx
Pathological features of West Nile and Usutu virus natural infections in wild and domestic animals and in humans: A comparative review
A Journey to the Central Nervous System: Routes of Flaviviral Neuroinvasion in Human Disease
September, 2022
Authors: Eleanor M. Marshall, Marion P. G. Koopmans and Barry Rockx